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Some villages became without young women largely. 4 Kuru offers disappeared from younger Fore population progressively, consistent with the cessation of endocannibalism in the late 1950s.5 Prion diseases are connected with a build up of a disease-related isoform of host-encoded prion protein through a posttranslational process involving conformational transformation and aggregation.7 A common coding polymorphism at codon 129 of the prion protein gene , where either methionine or valine may be encoded, is a solid susceptibility factor for individual prion diseases.2,16-18 Methods Study Design We obtained genealogic details and venous bloodstream samples from individuals with kuru and, when feasible, from healthy family members and community members, a few of whom had participated in multiple mortuary feasts.