.. Addition of inflammatory biomarkers to clinical variables improve mortality prediction in COPD The addition of changes in inflammatory biomarkers to established clinical variables improves the prediction of mortality in patients with chronic obstructive pulmonary disease , according to a fresh study. COPD is seen as a low-grade inflammation, so we hypothesized that the addition of inflammatory biomarkers to set up predictive factors would improve the prediction of mortality, stated lead writer Bartolome Celli, lecturer in medicine at Harvard Medical College and member of the Pulmonary and Important Treatment Division of Brigham and Women’s Hospital in Boston.Subjects who demonstrate disease control in the gefitinib only arm will cross-over upon progression to a combined mix of gefitinib and ficlatuzumab to assess whether obtained resistance to gefitinib can be overcome with the help of ficlatuzumab. Although molecular markers aren’t required for study entry, tumor cells has been obtained from the majority of sufferers for biomarker and correlative studies.
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