Catherine Determann.

Serum osteoprotegerin levels, measured through an enzyme-connected immunosorbent assay on two events, approximately 4 weeks apart; were 0.78 and 0.47 pmol per liter, respectively . Total serum RANKL levels, as measured with the use of an ELISA at the same time points, were 0.152 and 0.143 nmol per liter, respectively . The patient was given three infusions of 4 mg of zoledronic acid over a 3-month period. Following the initial infusion, the serum calcium level decreased to at least one 1.91 mmol per liter , accompanied by increases in the parathyroid hormone level to 163 ng per liter and in the 1,25-dihydroxyvitamin D level to 992 pmol per liter .This can result in sub-retinal and intravitreal hemorrhage, and retinal detachment tragically, which in turn causes blindness,’ explained lead author Dr. ‘For the very first time in this study, we’ve demonstrated that IRS-1, an angiogenic proteins, is usually expressed in the retina and that aganirsen can successfully attenuate neovascularization by inhibiting IRS-1 expression, without affecting normal vascularisation, ‘ noted co-lead writer Dr.