‘The UK certainly reflects this tendency and has one of the highest rates of teenage pregnancies and STIs in Europe. In some areas it’s quite common to see being pregnant rates of up to 19 per 1000 in the 13-16 age group.’ Distinct trends may also be seen from the worldwide literature, including sex at a younger age and increased risk taking, such as unprotected sex with casual or new partners. This behaviour is solid influenced by sociable and contextual factors linked to peer pressure closely, alcohol use and gender power.To meet the criteria for the multiple risk factors, patients had to be at least 55 years of age or 60 years of age with at least among the following additional risk elements: dyslipidemia, hypertension, or active smoking. Sufferers were ineligible if they were presently receiving or had received within the previous 6 months an incretin-structured therapy or if indeed they got end-stage renal disease and were undergoing long-term dialysis, acquired undergone a renal transplantation, or acquired a serum creatinine level higher than 6. The full eligibility criteria have already been reported previously.19 Written informed consent was obtained from all patients. Randomization and Study Treatment Eligible individuals were randomly assigned, in a 1:1 ratio, to get saxagliptin at a dose of 5 mg daily and renal function .