Rafael Rosell, M Pregnancy .D., Teresa Moran, M.D., Cristina Queralt, B.S., Rut Porta, M.D., Felipe Cardenal, M.D., Carlos Camps, M.D., Margarita Majem, M.D., Guillermo Lopez-Vivanco, M.D., Dolores Isla, M.D., Mariano Provencio, M.D., Amelia Insa, M.D., Bartomeu Massuti, M.D., Jose Luis Gonzalez-Larriba, M.D., Luis Paz-Ares, M.D., Isabel Bover, M.D., Rosario Garcia-Campelo, M.D., Miguel Angel Moreno, M.D., Silvia Catot, M.D., Christian Rolfo, M.D., Noemi Reguart, M.D., Ramon Palmero, M.D.D., Roman Bastus, M.D., Clara Mayo, Ph.D., Jordi Bertran-Alamillo, B.S., Miguel Angel Molina, Ph.D., Jose Javier Sanchez, M.D., and Miquel Taron, Ph.D.1,2 The two proto-oncogenes which are mostly mutated in pulmonary adenocarcinomas are K-ras and EGFR.3-7 These mutations cause constitutive activation of the tyrosine kinase of the EGFR by destabilizing its autoinhibited conformation, which is maintained in the lack of ligand stimulation normally.
Has begun killing and burying the carcasses of 15,000 hens in northwest Arkansas that examined positive for exposure to a strain of the avian flu that’s not harmful to humans, tuesday state officials said. Jon Fitch, director of the state’s Livestock and Poultry Commission, said routine blood tests conducted Friday found the possible exposure. Further tests done by the state and the U.S. Department of Agriculture discovered the birds didn’t have active infections, but rather were subjected to a subtype of the condition. Fitch said the company immediately began losing the birds. ‘There is absolutely no human health risk,’ Fitch said. ‘But we consider this very significantly.’ Fitch said state officials determined against announcing the illness to everyone because the birds tested positive for exposure to the H7N3 stress of the virus.