Shashikant Apte.

All authors participated in revising subsequent drafts of the manuscript and produced the final decision to post it for publication. Biogen Idec reviewed the manuscript and offered responses to the authors.e., experienced accrued at least 100 exposure days). Individuals were excluded if they had a brief history of development of inhibitors or anaphylaxis associated with element IX or intravenous immunoglobulin. Patients with additional coagulation disorders, uncontrolled disease with the human being immunodeficiency virus , renal dysfunction, or energetic hepatic disease had been excluded from the analysis.