Be sure your footwear is correctly fitted and broken-in before you hit the trail in order to reduce the risk of blisters, pain in the ankles and feet, and toenail harm, Catalano said. You’ll want to wear socks that cushion your toes, wick away wetness and protect from the cold. Know your walking route and your options so you can get medical help, this individual added. Carry supplies, such as wraps and bandages, which you can use to stabilize and protect injured ankles and feet. Some hikers underestimate the seriousness of an injury. For example, they make an effort to ease pain by changing the way they walk first, altering their speed, or by switching footwear. However in some full cases, such actions can cause further injury, Catalano warned. It is critical hikers know the signals and continually monitor for complex accidental injuries, as not seeking treatment may bring about additional damage that may lead to longer, more involved recovery and remedies periods, Catalano said.Kase, M.D., Kenneth Rice, Ph.D., Talin Haritunians, Ph.D., Gerwin Roks, M.D., Ph.D., Paul L.M. De Kort, M.D., Ph.D., Kent D. Taylor, Ph.D., Lonneke M. De Lau, M.D., Ph.D., Ben A. Oostra, Ph.D., Andre G. Uitterlinden, Ph.D., Jerome I. Rotter, M.D., Eric Boerwinkle, Ph.D., Bruce M. Psaty, M.D., Ph.D., Thomas H. Mosley, Ph.D., Cornelia M. Van Duijn, Ph.D., Monique M.B. Breteler, M.D., Ph.D., W.T. Longstreth, Jr., M.D., and Philip A. Wolf, M.D.: Genomewide Association Studies of Stroke Stroke may be the leading neurologic cause of disability and death.1 Twin and familial aggregation studies suggest that the risk of stroke includes a considerable genetic component,2-4 however the genes underlying this risk in the general population remain undetermined.