Merck CEO Richard Clark was quoted by The Wall structure Road Journal on the heels of closing the Schering-Plough merger as saying that another blockbuster offer is off the desk – – but a smaller sized biotech acquisition is not out of the question. Bristol-Myers Squibb will probably continue with smaller acquisitions, in keeping with the business’s string of pearls technique that focuses on small, high-value purchases. The acquisition of Medarex for $2.4 billion was just such a deal, as BMS added ipilimumab, a medication in development for numerous kinds of cancer, and also other important assets.The two paralogs showed different expression patterns, suggesting they have functionally diverged . When ATG-MO was used to disrupt cecr1b expression in mpx:EGFP transgenic zebrafish , in which neutrophils are labeled green, there was marked neutropenia . This phenotype was blocked by the coinjection of non-mutant human CECR1 mRNA but not by the coinjection of H112Q or R169Q mRNA, both which are connected with stroke in our patients. Effects of ADA2 Deficiency on Endothelial and Leukocyte Development Given the zebrafish data, we examined endothelial activation and integrity in individuals. Staining with anti-CD31 antibodies showed considerable endothelial harm in biopsy specimens from the mind and from lesional pores and skin . Endothelial-cell activation as shown by E-selectin staining was observed both in brain-biopsy specimens and in skin-biopsy specimens .