Protease Activity of Mutant HTRA1 The level of protease activity in the mutant HTRA1 encoded by cDNA containing V297M, A252T, or R302X was 21 percent to 50 percent of the experience level in wild-type HTRA1. In contrast, HTRA1 encoded by a construct including the R370X mutation had a protease activity level similar compared to that in wild-type HTRA1 .20 As the location of R370X fulfills this criterion for decay , we determined whether R370X-containing HTRA1 mRNA is degraded through nonsense-mediated decay. The amount of HTRA1 mRNA expression in fibroblasts from the individual with the R370X mutation was 6.0 percent of that in fibroblasts from control subjects, and treatment with cycloheximide, an inhibitor of nonsense-mediated decay, increased this level by a factor of four .Gradual bowel transit times. Quite simply they keep the food in the gut much longer. This means that the bacteria have more time to create acne-causing toxins. White flour products are also devoid of practically any nutrients that may clear up your skin layer. Dairy products are the third dietary weapon against very clear skin. Make an effort to use commercial milk products. They come packed with antibiotics and hormones which have been fed to dairy cows. I’m sure you remember how important antibiotics are in creating pimples – why no obtain the double whammy good thing about taking them along with dairy.